Pre-cataclysmic binary systems consisting of an M dwarf and a white dwarf can give clues about the mass-loss rate of the M dwarf component. Some white dwarfs exhibit metal lines in their spectra that can only be maintained if there is a steady supply of material. Assuming that the wind from the M dwarf is the source of this material, the mass-loss rate can be determined by analysis of the white dwarf spectrum (Debes, 2006).
By charge exchange between ions of a stellar wind ad the neutral ISM material, X-ray emission is produced. This X-ray emission can be used to determine the mass-loss rate of the star (Wargelin & Drake, 2001, 2002). No such emission has been detected yet, but with more sensitive instruments (e.g. the proposed Constellation-X and XEUS missions) this method could be a valuable diagnostic tool in the future, because it would also pe possible to determine the wind's velocity, composition and ionization state.
Until now, these methods yielded mass-loss rates for a small number of main-sequece stars in order of 10-16..10-12 M⊙/yr. Besides observational techniques, expected mass-loss rates can also be estimated using theoretical models. Holzwarth & Jardine (2007) developed a polytropic magnetized wind model applicable for winds of late-type stars. In this model the magnetic and thermal wind properties depend primarily on the stellar rotation rate. In this scenario, cool main-sequence stars can have mass-loss rates up to ten times solar.